1 Data preparation

1.1 Outline

  • Load scripts: loads libraries and useful scripts used in the analyses; all .R files contained in scripts at the root of the factory are automatically loaded

  • Load data: imports datasets, and may contain some ad hoc changes to the data such as specific data cleaning (not used in other reports), new variables used in the analyses, etc.

1.2 Load packages


library(reportfactory)
library(here)
library(rio) 
library(tidyverse)
library(incidence)
library(distcrete)
library(epitrix)
library(earlyR)
library(projections)
library(linelist)
library(remotes)
library(janitor)
library(kableExtra)
library(DT)
library(cyphr)
library(chngpt)
library(lubridate)
library(ggpubr)
library(ggnewscale)

1.3 Load scripts

These scripts will load:

  • all scripts stored as .R files inside /scripts/
  • all scripts stored as .R files inside /src/

These scripts also contain routines to access the latest clean encrypted data (see next section).


reportfactory::rfh_load_scripts()

1.4 Load clean data

We import the latest NHS pathways data:


x <- import_pathways() %>%
  as_tibble()
x
## # A tibble: 469,517 x 11
##    site_type date       sex    age   ccg_code ccg_name count postcode nhs_region
##    <chr>     <date>     <chr>  <chr> <chr>    <chr>    <int> <chr>    <chr>     
##  1 111       2020-03-18 female miss… e380000… nhs_glo…     1 gl34fe   South West
##  2 111       2020-03-18 female miss… e380001… nhs_sou…     1 ne325nn  North Eas…
##  3 111       2020-03-18 female 0-18  e380000… nhs_air…     8 bd57jr   North Eas…
##  4 111       2020-03-18 female 0-18  e380000… nhs_ash…     7 tn254ab  South East
##  5 111       2020-03-18 female 0-18  e380000… nhs_bar…    35 rm13ae   London    
##  6 111       2020-03-18 female 0-18  e380000… nhs_bar…     9 n111np   London    
##  7 111       2020-03-18 female 0-18  e380000… nhs_bar…    11 s752py   North Eas…
##  8 111       2020-03-18 female 0-18  e380000… nhs_bas…    19 ss143hg  East of E…
##  9 111       2020-03-18 female 0-18  e380000… nhs_bas…     6 dn227xf  North Eas…
## 10 111       2020-03-18 female 0-18  e380000… nhs_bat…     9 ba25rp   South West
## # … with 469,507 more rows, and 2 more variables: day <int>, weekday <fct>

We also import demographics data for NHS regions in England, used later in our analysis:


path <- here::here("data", "csv", "nhs_region_population_2018.csv")
nhs_region_pop <- rio::import(path) %>%
  mutate(nhs_region = str_to_title(gsub("_"," ",nhs_region)))

nhs_region_pop$nhs_region <- gsub(" Of ", " of ", nhs_region_pop$nhs_region)
nhs_region_pop$nhs_region <- gsub(" And ", " and ", nhs_region_pop$nhs_region)
nhs_region_pop
##                  nhs_region variable      value
## 1                North West     0-18 0.22538599
## 2  North East and Yorkshire     0-18 0.21876449
## 3                  Midlands     0-18 0.22564656
## 4           East of England     0-18 0.22810783
## 5                    London     0-18 0.23764782
## 6                South East     0-18 0.22458811
## 7                South West     0-18 0.20799797
## 8                North West    19-69 0.64274078
## 9  North East and Yorkshire    19-69 0.64437753
## 10                 Midlands    19-69 0.63876675
## 11          East of England    19-69 0.63034229
## 12                   London    19-69 0.67820084
## 13               South East    19-69 0.63267336
## 14               South West    19-69 0.63176131
## 15               North West   70-120 0.13187323
## 16 North East and Yorkshire   70-120 0.13685797
## 17                 Midlands   70-120 0.13558669
## 18          East of England   70-120 0.14154988
## 19                   London   70-120 0.08415135
## 20               South East   70-120 0.14273853
## 21               South West   70-120 0.16024072

Finally, we import publically available deaths per NHS region:


dth <- import_deaths() %>%
  mutate(nhs_region = str_to_title(gsub("_"," ",nhs_region)))

#truncation to account for reporting delay
delay_max <- 21

dth$nhs_region <- gsub(" Of ", " of ", dth$nhs_region)
dth$nhs_region <- gsub(" And ", " and ", dth$nhs_region)
dth
##      date_report               nhs_region deaths
## 1     2020-03-01          East of England      0
## 2     2020-03-02          East of England      1
## 3     2020-03-03          East of England      0
## 4     2020-03-04          East of England      0
## 5     2020-03-05          East of England      0
## 6     2020-03-06          East of England      1
## 7     2020-03-07          East of England      0
## 8     2020-03-08          East of England      0
## 9     2020-03-09          East of England      1
## 10    2020-03-10          East of England      0
## 11    2020-03-11          East of England      0
## 12    2020-03-12          East of England      0
## 13    2020-03-13          East of England      1
## 14    2020-03-14          East of England      2
## 15    2020-03-15          East of England      2
## 16    2020-03-16          East of England      1
## 17    2020-03-17          East of England      1
## 18    2020-03-18          East of England      5
## 19    2020-03-19          East of England      4
## 20    2020-03-20          East of England      2
## 21    2020-03-21          East of England     11
## 22    2020-03-22          East of England     12
## 23    2020-03-23          East of England     11
## 24    2020-03-24          East of England     19
## 25    2020-03-25          East of England     26
## 26    2020-03-26          East of England     36
## 27    2020-03-27          East of England     38
## 28    2020-03-28          East of England     28
## 29    2020-03-29          East of England     43
## 30    2020-03-30          East of England     45
## 31    2020-03-31          East of England     70
## 32    2020-04-01          East of England     63
## 33    2020-04-02          East of England     65
## 34    2020-04-03          East of England     80
## 35    2020-04-04          East of England     71
## 36    2020-04-05          East of England     76
## 37    2020-04-06          East of England     71
## 38    2020-04-07          East of England     93
## 39    2020-04-08          East of England    111
## 40    2020-04-09          East of England     87
## 41    2020-04-10          East of England     74
## 42    2020-04-11          East of England     92
## 43    2020-04-12          East of England    100
## 44    2020-04-13          East of England     78
## 45    2020-04-14          East of England     61
## 46    2020-04-15          East of England     82
## 47    2020-04-16          East of England     74
## 48    2020-04-17          East of England     86
## 49    2020-04-18          East of England     64
## 50    2020-04-19          East of England     67
## 51    2020-04-20          East of England     67
## 52    2020-04-21          East of England     75
## 53    2020-04-22          East of England     67
## 54    2020-04-23          East of England     49
## 55    2020-04-24          East of England     66
## 56    2020-04-25          East of England     54
## 57    2020-04-26          East of England     48
## 58    2020-04-27          East of England     46
## 59    2020-04-28          East of England     58
## 60    2020-04-29          East of England     32
## 61    2020-04-30          East of England     45
## 62    2020-05-01          East of England     49
## 63    2020-05-02          East of England     29
## 64    2020-05-03          East of England     41
## 65    2020-05-04          East of England     19
## 66    2020-05-05          East of England     36
## 67    2020-05-06          East of England     31
## 68    2020-05-07          East of England     33
## 69    2020-05-08          East of England     33
## 70    2020-05-09          East of England     29
## 71    2020-05-10          East of England     22
## 72    2020-05-11          East of England     18
## 73    2020-05-12          East of England     21
## 74    2020-05-13          East of England     27
## 75    2020-05-14          East of England     26
## 76    2020-05-15          East of England     19
## 77    2020-05-16          East of England     26
## 78    2020-05-17          East of England     17
## 79    2020-05-18          East of England     25
## 80    2020-05-19          East of England     15
## 81    2020-05-20          East of England     26
## 82    2020-05-21          East of England     21
## 83    2020-05-22          East of England     13
## 84    2020-05-23          East of England     12
## 85    2020-05-24          East of England     17
## 86    2020-05-25          East of England     25
## 87    2020-05-26          East of England     14
## 88    2020-05-27          East of England     12
## 89    2020-05-28          East of England     17
## 90    2020-05-29          East of England     16
## 91    2020-05-30          East of England      9
## 92    2020-05-31          East of England      8
## 93    2020-06-01          East of England     17
## 94    2020-06-02          East of England     14
## 95    2020-06-03          East of England     10
## 96    2020-06-04          East of England      7
## 97    2020-06-05          East of England     14
## 98    2020-06-06          East of England      5
## 99    2020-06-07          East of England      9
## 100   2020-06-08          East of England      7
## 101   2020-06-09          East of England      6
## 102   2020-06-10          East of England      8
## 103   2020-06-11          East of England      1
## 104   2020-06-12          East of England      9
## 105   2020-06-13          East of England      5
## 106   2020-06-14          East of England      4
## 107   2020-06-15          East of England      8
## 108   2020-06-16          East of England      3
## 109   2020-06-17          East of England      7
## 110   2020-06-18          East of England      4
## 111   2020-06-19          East of England      7
## 112   2020-06-20          East of England      4
## 113   2020-06-21          East of England      3
## 114   2020-06-22          East of England      6
## 115   2020-06-23          East of England      5
## 116   2020-06-24          East of England      4
## 117   2020-06-25          East of England      1
## 118   2020-06-26          East of England      6
## 119   2020-06-27          East of England      6
## 120   2020-06-28          East of England      8
## 121   2020-06-29          East of England      4
## 122   2020-06-30          East of England      5
## 123   2020-07-01          East of England      2
## 124   2020-07-02          East of England      5
## 125   2020-07-03          East of England      0
## 126   2020-07-04          East of England      3
## 127   2020-07-05          East of England      1
## 128   2020-07-06          East of England      2
## 129   2020-07-07          East of England      2
## 130   2020-07-08          East of England      0
## 131   2020-07-09          East of England      8
## 132   2020-07-10          East of England      4
## 133   2020-07-11          East of England      2
## 134   2020-07-12          East of England      1
## 135   2020-07-13          East of England      8
## 136   2020-07-14          East of England      2
## 137   2020-07-15          East of England      0
## 138   2020-07-16          East of England      0
## 139   2020-07-17          East of England      0
## 140   2020-07-18          East of England      0
## 141   2020-07-19          East of England      1
## 142   2020-07-20          East of England      1
## 143   2020-07-21          East of England      1
## 144   2020-07-22          East of England      2
## 145   2020-07-23          East of England      1
## 146   2020-07-24          East of England      1
## 147   2020-07-25          East of England      0
## 148   2020-07-26          East of England      1
## 149   2020-07-27          East of England      1
## 150   2020-07-28          East of England      2
## 151   2020-07-29          East of England      0
## 152   2020-07-30          East of England      0
## 153   2020-07-31          East of England      1
## 154   2020-08-01          East of England      0
## 155   2020-08-02          East of England      0
## 156   2020-08-03          East of England      0
## 157   2020-08-04          East of England      1
## 158   2020-08-05          East of England      1
## 159   2020-08-06          East of England      0
## 160   2020-08-07          East of England      1
## 161   2020-08-08          East of England      0
## 162   2020-08-09          East of England      0
## 163   2020-08-10          East of England      1
## 164   2020-08-11          East of England      2
## 165   2020-08-12          East of England      1
## 166   2020-08-13          East of England      0
## 167   2020-08-14          East of England      1
## 168   2020-08-15          East of England      1
## 169   2020-08-16          East of England      0
## 170   2020-08-17          East of England      0
## 171   2020-08-18          East of England      2
## 172   2020-08-19          East of England      1
## 173   2020-08-20          East of England      1
## 174   2020-08-21          East of England      0
## 175   2020-08-22          East of England      1
## 176   2020-08-23          East of England      1
## 177   2020-08-24          East of England      0
## 178   2020-08-25          East of England      0
## 179   2020-08-26          East of England      1
## 180   2020-08-27          East of England      1
## 181   2020-08-28          East of England      0
## 182   2020-08-29          East of England      0
## 183   2020-08-30          East of England      0
## 184   2020-08-31          East of England      0
## 185   2020-09-01          East of England      0
## 186   2020-09-02          East of England      0
## 187   2020-09-03          East of England      1
## 188   2020-09-04          East of England      1
## 189   2020-09-05          East of England      0
## 190   2020-09-06          East of England      1
## 191   2020-09-07          East of England      0
## 192   2020-09-08          East of England      0
## 193   2020-09-09          East of England      0
## 194   2020-09-10          East of England      0
## 195   2020-09-11          East of England      0
## 196   2020-09-12          East of England      0
## 197   2020-09-13          East of England      1
## 198   2020-09-14          East of England      1
## 199   2020-09-15          East of England      0
## 200   2020-09-16          East of England      0
## 201   2020-09-17          East of England      0
## 202   2020-09-18          East of England      0
## 203   2020-09-19          East of England      0
## 204   2020-09-20          East of England      2
## 205   2020-09-21          East of England      0
## 206   2020-09-22          East of England      2
## 207   2020-09-23          East of England      1
## 208   2020-09-24          East of England      0
## 209   2020-09-25          East of England      1
## 210   2020-09-26          East of England      1
## 211   2020-09-27          East of England      1
## 212   2020-09-28          East of England      2
## 213   2020-09-29          East of England      2
## 214   2020-09-30          East of England      2
## 215   2020-10-01          East of England      2
## 216   2020-10-02          East of England      1
## 217   2020-10-03          East of England      1
## 218   2020-10-04          East of England      0
## 219   2020-10-05          East of England      0
## 220   2020-10-06          East of England      4
## 221   2020-10-07          East of England      6
## 222   2020-10-08          East of England      3
## 223   2020-10-09          East of England      1
## 224   2020-10-10          East of England      6
## 225   2020-10-11          East of England      2
## 226   2020-10-12          East of England      2
## 227   2020-10-13          East of England      1
## 228   2020-10-14          East of England      3
## 229   2020-10-15          East of England      4
## 230   2020-10-16          East of England      5
## 231   2020-10-17          East of England      6
## 232   2020-10-18          East of England      7
## 233   2020-10-19          East of England      5
## 234   2020-10-20          East of England      9
## 235   2020-10-21          East of England      8
## 236   2020-10-22          East of England      7
## 237   2020-10-23          East of England     14
## 238   2020-10-24          East of England      1
## 239   2020-10-25          East of England     10
## 240   2020-10-26          East of England     10
## 241   2020-10-27          East of England      8
## 242   2020-10-28          East of England     12
## 243   2020-10-29          East of England     10
## 244   2020-10-30          East of England     12
## 245   2020-10-31          East of England     15
## 246   2020-11-01          East of England     14
## 247   2020-11-02          East of England      9
## 248   2020-11-03          East of England     14
## 249   2020-11-04          East of England     11
## 250   2020-11-05          East of England     12
## 251   2020-11-06          East of England     19
## 252   2020-11-07          East of England     10
## 253   2020-11-08          East of England     13
## 254   2020-11-09          East of England     16
## 255   2020-11-10          East of England     26
## 256   2020-11-11          East of England     14
## 257   2020-11-12          East of England     14
## 258   2020-11-13          East of England     21
## 259   2020-11-14          East of England     19
## 260   2020-11-15          East of England     13
## 261   2020-11-16          East of England     11
## 262   2020-11-17          East of England     17
## 263   2020-11-18          East of England     19
## 264   2020-11-19          East of England     23
## 265   2020-11-20          East of England     24
## 266   2020-11-21          East of England     19
## 267   2020-11-22          East of England     21
## 268   2020-11-23          East of England     18
## 269   2020-11-24          East of England     21
## 270   2020-11-25          East of England     19
## 271   2020-11-26          East of England     19
## 272   2020-11-27          East of England     14
## 273   2020-11-28          East of England     28
## 274   2020-11-29          East of England     19
## 275   2020-11-30          East of England     22
## 276   2020-12-01          East of England     26
## 277   2020-12-02          East of England     18
## 278   2020-12-03          East of England     24
## 279   2020-12-04          East of England     25
## 280   2020-12-05          East of England     25
## 281   2020-12-06          East of England     22
## 282   2020-12-07          East of England     16
## 283   2020-12-08          East of England     26
## 284   2020-12-09          East of England     20
## 285   2020-12-10          East of England     32
## 286   2020-12-11          East of England     32
## 287   2020-12-12          East of England     27
## 288   2020-12-13          East of England     25
## 289   2020-12-14          East of England     32
## 290   2020-12-15          East of England     35
## 291   2020-12-16          East of England     29
## 292   2020-12-17          East of England     43
## 293   2020-12-18          East of England     44
## 294   2020-12-19          East of England     54
## 295   2020-12-20          East of England     52
## 296   2020-12-21          East of England     66
## 297   2020-12-22          East of England     52
## 298   2020-12-23          East of England     62
## 299   2020-12-24          East of England     61
## 300   2020-12-25          East of England     58
## 301   2020-12-26          East of England     64
## 302   2020-12-27          East of England     54
## 303   2020-12-28          East of England     71
## 304   2020-12-29          East of England     54
## 305   2020-12-30          East of England     76
## 306   2020-12-31          East of England     82
## 307   2021-01-01          East of England     90
## 308   2021-01-02          East of England     66
## 309   2021-01-03          East of England     78
## 310   2021-01-04          East of England     88
## 311   2021-01-05          East of England    102
## 312   2021-01-06          East of England    100
## 313   2021-01-07          East of England    116
## 314   2021-01-08          East of England     97
## 315   2021-01-09          East of England    133
## 316   2021-01-10          East of England    125
## 317   2021-01-11          East of England    126
## 318   2021-01-12          East of England    131
## 319   2021-01-13          East of England    131
## 320   2021-01-14          East of England    128
## 321   2021-01-15          East of England    119
## 322   2021-01-16          East of England    132
## 323   2021-01-17          East of England    133
## 324   2021-01-18          East of England    120
## 325   2021-01-19          East of England    130
## 326   2021-01-20          East of England    147
## 327   2021-01-21          East of England    136
## 328   2021-01-22          East of England    123
## 329   2021-01-23          East of England    102
## 330   2021-01-24          East of England    101
## 331   2021-01-25          East of England    114
## 332   2021-01-26          East of England     89
## 333   2021-01-27          East of England     94
## 334   2021-01-28          East of England    110
## 335   2021-01-29          East of England     96
## 336   2021-01-30          East of England     85
## 337   2021-01-31          East of England     74
## 338   2021-02-01          East of England     67
## 339   2021-02-02          East of England     75
## 340   2021-02-03          East of England     82
## 341   2021-02-04          East of England     75
## 342   2021-02-05          East of England     66
## 343   2021-02-06          East of England     78
## 344   2021-02-07          East of England     62
## 345   2021-02-08          East of England     73
## 346   2021-02-09          East of England     63
## 347   2021-02-10          East of England     53
## 348   2021-02-11          East of England     52
## 349   2021-02-12          East of England     47
## 350   2021-02-13          East of England     47
## 351   2021-02-14          East of England     33
## 352   2021-02-15          East of England     48
## 353   2021-02-16          East of England     47
## 354   2021-02-17          East of England     46
## 355   2021-02-18          East of England     31
## 356   2021-02-19          East of England     28
## 357   2021-02-20          East of England     30
## 358   2021-02-21          East of England     24
## 359   2021-02-22          East of England     26
## 360   2021-02-23          East of England     28
## 361   2021-02-24          East of England     17
## 362   2021-02-25          East of England     23
## 363   2021-02-26          East of England     15
## 364   2021-02-27          East of England     23
## 365   2021-02-28          East of England     17
## 366   2021-03-01          East of England     18
## 367   2021-03-02          East of England     19
## 368   2021-03-03          East of England     12
## 369   2021-03-04          East of England     18
## 370   2021-03-05          East of England     12
## 371   2021-03-06          East of England     12
## 372   2021-03-07          East of England     15
## 373   2021-03-08          East of England     15
## 374   2021-03-09          East of England     12
## 375   2021-03-10          East of England      9
## 376   2021-03-11          East of England     11
## 377   2021-03-12          East of England      4
## 378   2021-03-13          East of England     10
## 379   2021-03-14          East of England      6
## 380   2021-03-15          East of England      6
## 381   2021-03-16          East of England      7
## 382   2021-03-17          East of England      5
## 383   2021-03-18          East of England      0
## 384   2020-03-01                   London      0
## 385   2020-03-02                   London      0
## 386   2020-03-03                   London      0
## 387   2020-03-04                   London      0
## 388   2020-03-05                   London      0
## 389   2020-03-06                   London      1
## 390   2020-03-07                   London      0
## 391   2020-03-08                   London      0
## 392   2020-03-09                   London      1
## 393   2020-03-10                   London      0
## 394   2020-03-11                   London      5
## 395   2020-03-12                   London      6
## 396   2020-03-13                   London     10
## 397   2020-03-14                   London     13
## 398   2020-03-15                   London      9
## 399   2020-03-16                   London     15
## 400   2020-03-17                   London     23
## 401   2020-03-18                   London     28
## 402   2020-03-19                   London     25
## 403   2020-03-20                   London     44
## 404   2020-03-21                   London     49
## 405   2020-03-22                   London     54
## 406   2020-03-23                   London     63
## 407   2020-03-24                   London     86
## 408   2020-03-25                   London    112
## 409   2020-03-26                   London    130
## 410   2020-03-27                   London    130
## 411   2020-03-28                   London    123
## 412   2020-03-29                   London    145
## 413   2020-03-30                   London    151
## 414   2020-03-31                   London    183
## 415   2020-04-01                   London    202
## 416   2020-04-02                   London    191
## 417   2020-04-03                   London    199
## 418   2020-04-04                   London    231
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## 1448  2020-12-24 North East and Yorkshire     50
## 1449  2020-12-25 North East and Yorkshire     57
## 1450  2020-12-26 North East and Yorkshire     67
## 1451  2020-12-27 North East and Yorkshire     73
## 1452  2020-12-28 North East and Yorkshire     64
## 1453  2020-12-29 North East and Yorkshire     58
## 1454  2020-12-30 North East and Yorkshire     41
## 1455  2020-12-31 North East and Yorkshire     51
## 1456  2021-01-01 North East and Yorkshire     71
## 1457  2021-01-02 North East and Yorkshire     59
## 1458  2021-01-03 North East and Yorkshire     48
## 1459  2021-01-04 North East and Yorkshire     64
## 1460  2021-01-05 North East and Yorkshire     64
## 1461  2021-01-06 North East and Yorkshire     61
## 1462  2021-01-07 North East and Yorkshire     73
## 1463  2021-01-08 North East and Yorkshire     68
## 1464  2021-01-09 North East and Yorkshire     58
## 1465  2021-01-10 North East and Yorkshire     80
## 1466  2021-01-11 North East and Yorkshire     82
## 1467  2021-01-12 North East and Yorkshire     69
## 1468  2021-01-13 North East and Yorkshire     77
## 1469  2021-01-14 North East and Yorkshire     71
## 1470  2021-01-15 North East and Yorkshire     97
## 1471  2021-01-16 North East and Yorkshire     99
## 1472  2021-01-17 North East and Yorkshire     76
## 1473  2021-01-18 North East and Yorkshire     82
## 1474  2021-01-19 North East and Yorkshire    104
## 1475  2021-01-20 North East and Yorkshire     92
## 1476  2021-01-21 North East and Yorkshire     87
## 1477  2021-01-22 North East and Yorkshire     80
## 1478  2021-01-23 North East and Yorkshire     69
## 1479  2021-01-24 North East and Yorkshire     63
## 1480  2021-01-25 North East and Yorkshire     79
## 1481  2021-01-26 North East and Yorkshire     73
## 1482  2021-01-27 North East and Yorkshire     70
## 1483  2021-01-28 North East and Yorkshire     72
## 1484  2021-01-29 North East and Yorkshire     84
## 1485  2021-01-30 North East and Yorkshire     76
## 1486  2021-01-31 North East and Yorkshire     81
## 1487  2021-02-01 North East and Yorkshire     79
## 1488  2021-02-02 North East and Yorkshire     70
## 1489  2021-02-03 North East and Yorkshire     82
## 1490  2021-02-04 North East and Yorkshire     70
## 1491  2021-02-05 North East and Yorkshire     80
## 1492  2021-02-06 North East and Yorkshire     52
## 1493  2021-02-07 North East and Yorkshire     59
## 1494  2021-02-08 North East and Yorkshire     51
## 1495  2021-02-09 North East and Yorkshire     53
## 1496  2021-02-10 North East and Yorkshire     62
## 1497  2021-02-11 North East and Yorkshire     66
## 1498  2021-02-12 North East and Yorkshire     59
## 1499  2021-02-13 North East and Yorkshire     53
## 1500  2021-02-14 North East and Yorkshire     59
## 1501  2021-02-15 North East and Yorkshire     60
## 1502  2021-02-16 North East and Yorkshire     48
## 1503  2021-02-17 North East and Yorkshire     48
## 1504  2021-02-18 North East and Yorkshire     48
## 1505  2021-02-19 North East and Yorkshire     43
## 1506  2021-02-20 North East and Yorkshire     38
## 1507  2021-02-21 North East and Yorkshire     39
## 1508  2021-02-22 North East and Yorkshire     20
## 1509  2021-02-23 North East and Yorkshire     36
## 1510  2021-02-24 North East and Yorkshire     32
## 1511  2021-02-25 North East and Yorkshire     29
## 1512  2021-02-26 North East and Yorkshire     26
## 1513  2021-02-27 North East and Yorkshire     32
## 1514  2021-02-28 North East and Yorkshire     28
## 1515  2021-03-01 North East and Yorkshire     19
## 1516  2021-03-02 North East and Yorkshire     16
## 1517  2021-03-03 North East and Yorkshire     28
## 1518  2021-03-04 North East and Yorkshire     16
## 1519  2021-03-05 North East and Yorkshire     27
## 1520  2021-03-06 North East and Yorkshire     21
## 1521  2021-03-07 North East and Yorkshire     19
## 1522  2021-03-08 North East and Yorkshire     20
## 1523  2021-03-09 North East and Yorkshire     22
## 1524  2021-03-10 North East and Yorkshire     15
## 1525  2021-03-11 North East and Yorkshire     14
## 1526  2021-03-12 North East and Yorkshire     16
## 1527  2021-03-13 North East and Yorkshire     14
## 1528  2021-03-14 North East and Yorkshire     12
## 1529  2021-03-15 North East and Yorkshire     13
## 1530  2021-03-16 North East and Yorkshire     11
## 1531  2021-03-17 North East and Yorkshire      6
## 1532  2021-03-18 North East and Yorkshire      4
## 1533  2020-03-01               North West      0
## 1534  2020-03-02               North West      0
## 1535  2020-03-03               North West      0
## 1536  2020-03-04               North West      0
## 1537  2020-03-05               North West      1
## 1538  2020-03-06               North West      0
## 1539  2020-03-07               North West      0
## 1540  2020-03-08               North West      1
## 1541  2020-03-09               North West      0
## 1542  2020-03-10               North West      0
## 1543  2020-03-11               North West      0
## 1544  2020-03-12               North West      2
## 1545  2020-03-13               North West      3
## 1546  2020-03-14               North West      1
## 1547  2020-03-15               North West      4
## 1548  2020-03-16               North West      2
## 1549  2020-03-17               North West      4
## 1550  2020-03-18               North West      6
## 1551  2020-03-19               North West      7
## 1552  2020-03-20               North West     10
## 1553  2020-03-21               North West     11
## 1554  2020-03-22               North West     13
## 1555  2020-03-23               North West     15
## 1556  2020-03-24               North West     21
## 1557  2020-03-25               North West     21
## 1558  2020-03-26               North West     29
## 1559  2020-03-27               North West     36
## 1560  2020-03-28               North West     28
## 1561  2020-03-29               North West     46
## 1562  2020-03-30               North West     67
## 1563  2020-03-31               North West     52
## 1564  2020-04-01               North West     86
## 1565  2020-04-02               North West     96
## 1566  2020-04-03               North West     95
## 1567  2020-04-04               North West     98
## 1568  2020-04-05               North West    102
## 1569  2020-04-06               North West    100
## 1570  2020-04-07               North West    136
## 1571  2020-04-08               North West    127
## 1572  2020-04-09               North West    119
## 1573  2020-04-10               North West    117
## 1574  2020-04-11               North West    138
## 1575  2020-04-12               North West    125
## 1576  2020-04-13               North West    130
## 1577  2020-04-14               North West    130
## 1578  2020-04-15               North West    114
## 1579  2020-04-16               North West    135
## 1580  2020-04-17               North West     98
## 1581  2020-04-18               North West    114
## 1582  2020-04-19               North West     71
## 1583  2020-04-20               North West     83
## 1584  2020-04-21               North West     76
## 1585  2020-04-22               North West     87
## 1586  2020-04-23               North West     85
## 1587  2020-04-24               North West     67
## 1588  2020-04-25               North West     67
## 1589  2020-04-26               North West     55
## 1590  2020-04-27               North West     54
## 1591  2020-04-28               North West     57
## 1592  2020-04-29               North West     64
## 1593  2020-04-30               North West     60
## 1594  2020-05-01               North West     45
## 1595  2020-05-02               North West     56
## 1596  2020-05-03               North West     55
## 1597  2020-05-04               North West     48
## 1598  2020-05-05               North West     49
## 1599  2020-05-06               North West     44
## 1600  2020-05-07               North West     50
## 1601  2020-05-08               North West     43
## 1602  2020-05-09               North West     31
## 1603  2020-05-10               North West     42
## 1604  2020-05-11               North West     35
## 1605  2020-05-12               North West     38
## 1606  2020-05-13               North West     25
## 1607  2020-05-14               North West     26
## 1608  2020-05-15               North West     33
## 1609  2020-05-16               North West     32
## 1610  2020-05-17               North West     24
## 1611  2020-05-18               North West     31
## 1612  2020-05-19               North West     35
## 1613  2020-05-20               North West     27
## 1614  2020-05-21               North West     28
## 1615  2020-05-22               North West     26
## 1616  2020-05-23               North West     31
## 1617  2020-05-24               North West     26
## 1618  2020-05-25               North West     31
## 1619  2020-05-26               North West     27
## 1620  2020-05-27               North West     27
## 1621  2020-05-28               North West     28
## 1622  2020-05-29               North West     20
## 1623  2020-05-30               North West     19
## 1624  2020-05-31               North West     13
## 1625  2020-06-01               North West     12
## 1626  2020-06-02               North West     27
## 1627  2020-06-03               North West     22
## 1628  2020-06-04               North West     22
## 1629  2020-06-05               North West     16
## 1630  2020-06-06               North West     26
## 1631  2020-06-07               North West     20
## 1632  2020-06-08               North West     23
## 1633  2020-06-09               North West     17
## 1634  2020-06-10               North West     16
## 1635  2020-06-11               North West     16
## 1636  2020-06-12               North West     11
## 1637  2020-06-13               North West     10
## 1638  2020-06-14               North West     15
## 1639  2020-06-15               North West     16
## 1640  2020-06-16               North West     16
## 1641  2020-06-17               North West     13
## 1642  2020-06-18               North West     14
## 1643  2020-06-19               North West      7
## 1644  2020-06-20               North West     11
## 1645  2020-06-21               North West      8
## 1646  2020-06-22               North West     11
## 1647  2020-06-23               North West     13
## 1648  2020-06-24               North West     13
## 1649  2020-06-25               North West     15
## 1650  2020-06-26               North West      6
## 1651  2020-06-27               North West      7
## 1652  2020-06-28               North West      9
## 1653  2020-06-29               North West      9
## 1654  2020-06-30               North West      7
## 1655  2020-07-01               North West      3
## 1656  2020-07-02               North West      6
## 1657  2020-07-03               North West      7
## 1658  2020-07-04               North West      4
## 1659  2020-07-05               North West      6
## 1660  2020-07-06               North West      9
## 1661  2020-07-07               North West      8
## 1662  2020-07-08               North West      5
## 1663  2020-07-09               North West     10
## 1664  2020-07-10               North West      2
## 1665  2020-07-11               North West      5
## 1666  2020-07-12               North West      0
## 1667  2020-07-13               North West      6
## 1668  2020-07-14               North West      4
## 1669  2020-07-15               North West      5
## 1670  2020-07-16               North West      2
## 1671  2020-07-17               North West      4
## 1672  2020-07-18               North West      5
## 1673  2020-07-19               North West      3
## 1674  2020-07-20               North West      0
## 1675  2020-07-21               North West      2
## 1676  2020-07-22               North West      3
## 1677  2020-07-23               North West      3
## 1678  2020-07-24               North West      1
## 1679  2020-07-25               North West      1
## 1680  2020-07-26               North West      3
## 1681  2020-07-27               North West      1
## 1682  2020-07-28               North West      1
## 1683  2020-07-29               North West      2
## 1684  2020-07-30               North West      2
## 1685  2020-07-31               North West      0
## 1686  2020-08-01               North West      2
## 1687  2020-08-02               North West      1
## 1688  2020-08-03               North West      8
## 1689  2020-08-04               North West      3
## 1690  2020-08-05               North West      2
## 1691  2020-08-06               North West      2
## 1692  2020-08-07               North West      2
## 1693  2020-08-08               North West      2
## 1694  2020-08-09               North West      3
## 1695  2020-08-10               North West      2
## 1696  2020-08-11               North West      3
## 1697  2020-08-12               North West      0
## 1698  2020-08-13               North West      2
## 1699  2020-08-14               North West      2
## 1700  2020-08-15               North West      6
## 1701  2020-08-16               North West      2
## 1702  2020-08-17               North West      1
## 1703  2020-08-18               North West      2
## 1704  2020-08-19               North West      1
## 1705  2020-08-20               North West      1
## 1706  2020-08-21               North West      4
## 1707  2020-08-22               North West      3
## 1708  2020-08-23               North West      5
## 1709  2020-08-24               North West      4
## 1710  2020-08-25               North West      3
## 1711  2020-08-26               North West      4
## 1712  2020-08-27               North West      1
## 1713  2020-08-28               North West      2
## 1714  2020-08-29               North West      0
## 1715  2020-08-30               North West      2
## 1716  2020-08-31               North West      3
## 1717  2020-09-01               North West      0
## 1718  2020-09-02               North West      2
## 1719  2020-09-03               North West      1
## 1720  2020-09-04               North West      3
## 1721  2020-09-05               North West      6
## 1722  2020-09-06               North West      1
## 1723  2020-09-07               North West      8
## 1724  2020-09-08               North West      6
## 1725  2020-09-09               North West      5
## 1726  2020-09-10               North West      5
## 1727  2020-09-11               North West      1
## 1728  2020-09-12               North West      4
## 1729  2020-09-13               North West      2
## 1730  2020-09-14               North West      4
## 1731  2020-09-15               North West      4
## 1732  2020-09-16               North West      6
## 1733  2020-09-17               North West      7
## 1734  2020-09-18               North West      6
## 1735  2020-09-19               North West      3
## 1736  2020-09-20               North West      2
## 1737  2020-09-21               North West      2
## 1738  2020-09-22               North West      9
## 1739  2020-09-23               North West     14
## 1740  2020-09-24               North West     10
## 1741  2020-09-25               North West      8
## 1742  2020-09-26               North West     14
## 1743  2020-09-27               North West     11
## 1744  2020-09-28               North West     15
## 1745  2020-09-29               North West     12
## 1746  2020-09-30               North West     17
## 1747  2020-10-01               North West     17
## 1748  2020-10-02               North West     20
## 1749  2020-10-03               North West     15
## 1750  2020-10-04               North West     15
## 1751  2020-10-05               North West     15
## 1752  2020-10-06               North West     20
## 1753  2020-10-07               North West     20
## 1754  2020-10-08               North West     22
## 1755  2020-10-09               North West     24
## 1756  2020-10-10               North West     31
## 1757  2020-10-11               North West     31
## 1758  2020-10-12               North West     35
## 1759  2020-10-13               North West     26
## 1760  2020-10-14               North West     35
## 1761  2020-10-15               North West     36
## 1762  2020-10-16               North West     34
## 1763  2020-10-17               North West     52
## 1764  2020-10-18               North West     40
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## 1766  2020-10-20               North West     48
## 1767  2020-10-21               North West     51
## 1768  2020-10-22               North West     49
## 1769  2020-10-23               North West     50
## 1770  2020-10-24               North West     51
## 1771  2020-10-25               North West     63
## 1772  2020-10-26               North West     53
## 1773  2020-10-27               North West     49
## 1774  2020-10-28               North West     57
## 1775  2020-10-29               North West     74
## 1776  2020-10-30               North West     73
## 1777  2020-10-31               North West     63
## 1778  2020-11-01               North West     76
## 1779  2020-11-02               North West     65
## 1780  2020-11-03               North West     77
## 1781  2020-11-04               North West     64
## 1782  2020-11-05               North West     67
## 1783  2020-11-06               North West     76
## 1784  2020-11-07               North West     79
## 1785  2020-11-08               North West     83
## 1786  2020-11-09               North West     82
## 1787  2020-11-10               North West     68
## 1788  2020-11-11               North West     62
## 1789  2020-11-12               North West     64
## 1790  2020-11-13               North West     81
## 1791  2020-11-14               North West     61
## 1792  2020-11-15               North West     75
## 1793  2020-11-16               North West     74
## 1794  2020-11-17               North West     73
## 1795  2020-11-18               North West     71
## 1796  2020-11-19               North West     67
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## 1807  2020-11-30               North West     48
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## 1809  2020-12-02               North West     48
## 1810  2020-12-03               North West     47
## 1811  2020-12-04               North West     48
## 1812  2020-12-05               North West     37
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## 1815  2020-12-08               North West     49
## 1816  2020-12-09               North West     48
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## 1818  2020-12-11               North West     41
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## 1820  2020-12-13               North West     42
## 1821  2020-12-14               North West     51
## 1822  2020-12-15               North West     34
## 1823  2020-12-16               North West     41
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## 1825  2020-12-18               North West     47
## 1826  2020-12-19               North West     45
## 1827  2020-12-20               North West     37
## 1828  2020-12-21               North West     51
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## 1838  2020-12-31               North West     62
## 1839  2021-01-01               North West     54
## 1840  2021-01-02               North West     55
## 1841  2021-01-03               North West     57
## 1842  2021-01-04               North West     51
## 1843  2021-01-05               North West     56
## 1844  2021-01-06               North West     69
## 1845  2021-01-07               North West     61
## 1846  2021-01-08               North West     65
## 1847  2021-01-09               North West     70
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## 1849  2021-01-11               North West     79
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## 1851  2021-01-13               North West     85
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## 1859  2021-01-21               North West     85
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## 1869  2021-01-31               North West     85
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## 1871  2021-02-02               North West     82
## 1872  2021-02-03               North West     71
## 1873  2021-02-04               North West     79
## 1874  2021-02-05               North West     67
## 1875  2021-02-06               North West     62
## 1876  2021-02-07               North West     53
## 1877  2021-02-08               North West     73
## 1878  2021-02-09               North West     69
## 1879  2021-02-10               North West     72
## 1880  2021-02-11               North West     67
## 1881  2021-02-12               North West     67
## 1882  2021-02-13               North West     62
## 1883  2021-02-14               North West     50
## 1884  2021-02-15               North West     56
## 1885  2021-02-16               North West     55
## 1886  2021-02-17               North West     55
## 1887  2021-02-18               North West     52
## 1888  2021-02-19               North West     40
## 1889  2021-02-20               North West     34
## 1890  2021-02-21               North West     36
## 1891  2021-02-22               North West     25
## 1892  2021-02-23               North West     35
## 1893  2021-02-24               North West     34
## 1894  2021-02-25               North West     22
## 1895  2021-02-26               North West     38
## 1896  2021-02-27               North West     26
## 1897  2021-02-28               North West     32
## 1898  2021-03-01               North West     31
## 1899  2021-03-02               North West     13
## 1900  2021-03-03               North West     21
## 1901  2021-03-04               North West     12
## 1902  2021-03-05               North West     25
## 1903  2021-03-06               North West     14
## 1904  2021-03-07               North West     23
## 1905  2021-03-08               North West     16
## 1906  2021-03-09               North West     14
## 1907  2021-03-10               North West     12
## 1908  2021-03-11               North West     17
## 1909  2021-03-12               North West     10
## 1910  2021-03-13               North West     10
## 1911  2021-03-14               North West     19
## 1912  2021-03-15               North West     16
## 1913  2021-03-16               North West     11
## 1914  2021-03-17               North West      9
## 1915  2021-03-18               North West      0
## 1916  2020-03-01               South East      0
## 1917  2020-03-02               South East      0
## 1918  2020-03-03               South East      1
## 1919  2020-03-04               South East      0
## 1920  2020-03-05               South East      1
## 1921  2020-03-06               South East      0
## 1922  2020-03-07               South East      0
## 1923  2020-03-08               South East      1
## 1924  2020-03-09               South East      1
## 1925  2020-03-10               South East      1
## 1926  2020-03-11               South East      1
## 1927  2020-03-12               South East      0
## 1928  2020-03-13               South East      1
## 1929  2020-03-14               South East      1
## 1930  2020-03-15               South East      5
## 1931  2020-03-16               South East      8
## 1932  2020-03-17               South East      7
## 1933  2020-03-18               South East     10
## 1934  2020-03-19               South East      9
## 1935  2020-03-20               South East     13
## 1936  2020-03-21               South East      7
## 1937  2020-03-22               South East     25
## 1938  2020-03-23               South East     20
## 1939  2020-03-24               South East     22
## 1940  2020-03-25               South East     29
## 1941  2020-03-26               South East     35
## 1942  2020-03-27               South East     36
## 1943  2020-03-28               South East     36
## 1944  2020-03-29               South East     55
## 1945  2020-03-30               South East     58
## 1946  2020-03-31               South East     65
## 1947  2020-04-01               South East     66
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## 2455  2020-08-04               South West      0
## 2456  2020-08-05               South West      0
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## 2495  2020-09-13               South West      1
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## 2498  2020-09-16               South West      0
## 2499  2020-09-17               South West      1
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## 2506  2020-09-24               South West      1
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## 2518  2020-10-06               South West      1
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## 2524  2020-10-12               South West      2
## 2525  2020-10-13               South West      0
## 2526  2020-10-14               South West      3
## 2527  2020-10-15               South West      1
## 2528  2020-10-16               South West      2
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## 2530  2020-10-18               South West      2
## 2531  2020-10-19               South West      2
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## 2536  2020-10-24               South West      5
## 2537  2020-10-25               South West      5
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## 2539  2020-10-27               South West      6
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## 2557  2020-11-14               South West      8
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## 2564  2020-11-21               South West     25
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## 2632  2021-01-28               South West     52
## 2633  2021-01-29               South West     42
## 2634  2021-01-30               South West     39
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## 2670  2021-03-07               South West      1
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## 2674  2021-03-11               South West      2
## 2675  2021-03-12               South West      2
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## 2677  2021-03-14               South West      2
## 2678  2021-03-15               South West      3
## 2679  2021-03-16               South West      1
## 2680  2021-03-17               South West      4
## 2681  2021-03-18               South West      0

1.5 Completion date

We extract the completion date from the NHS Pathways file timestamp:


database_date <- attr(x, "timestamp")
database_date
## [1] "2021-03-18"

The completion date of the NHS Pathways data is Thursday 18 Mar 2021.

1.6 Auxiliary functions

These are functions which will be used further in the analyses.

Function to estimate the generalised R-squared as the proportion of deviance explained by a given model:


## Function to calculate R2 for Poisson model
## not adjusted for model complexity but all models have the same DF here

Rsq <- function(x) {
  1 - (x$deviance / x$null.deviance)
}

Function to extract growth rates per region as well as halving times, and the associated 95% confidence intervals:


## function to extract the coefficients, find the level of the intercept,
## reconstruct the values of r, get confidence intervals

get_r <- function(model) {
  ##  extract coefficients and conf int
  out <- data.frame(r = coef(model))  %>%
    rownames_to_column("var") %>% 
    cbind(confint(model)) %>%
    filter(!grepl("day_of_week", var)) %>% 
    filter(grepl("day", var)) %>%
    rename(lower_95 = "2.5 %",
           upper_95 = "97.5 %") %>%
    mutate(var = sub("day:", "", var))
  
  ## reconstruct values: intercept + region-coefficient
  for (i in 2:nrow(out)) {
    out[i, -1] <- out[1, -1] + out[i, -1]
  }
  
  ## find the name of the intercept, restore regions names
  out <- out %>%
    mutate(nhs_region = model$xlevels$nhs_region) %>%
    select(nhs_region, everything(), -var)
  
  ## find halving times
  halving <- log(0.5) / out[,-1] %>%
    rename(halving_t = r,
           halving_t_lower_95 = lower_95,
           halving_t_upper_95 = upper_95)
  
  ## set halving times with exclusion intervals to NA
  no_halving <- out$lower_95 < 0 & out$upper_95 > 0
  halving[no_halving, ] <- NA_real_
  
  ## return all data
  cbind(out, halving)
  
}

Functions used in the correlation analysis between NHS Pathways reports and deaths:

## Function to calculate Pearson's correlation between deaths and lagged
## reports. Note that `pearson` can be replaced with `spearman` for rank
## correlation.

getcor <- function(x, ndx) {
  return(cor(x$deaths[ndx],
             x$note_lag[ndx],
             use = "complete.obs",
             method = "pearson"))
}

## Catch if sample size throws an error
getcor2 <- possibly(getcor, otherwise = NA)

getboot <- function(x) {
  result <- boot::boot.ci(boot::boot(x, getcor2, R = 1000), 
                           type = "bca")
  return(data.frame(n = sum(!is.na(x$note_lag) & !is.na(x$deaths)),
                    r = result$t0,
                    r_low = result$bca[4],
                    r_hi = result$bca[5]))
}

Function to classify the day of the week into weekend, Monday, and the rest:


## Fn to add day of week
day_of_week <- function(df) {
  df %>% 
    dplyr::mutate(day_of_week = lubridate::wday(date, label = TRUE)) %>% 
    dplyr::mutate(day_of_week = dplyr::case_when(
      day_of_week %in% c("Sat", "Sun") ~ "weekend",
      day_of_week %in% c("Mon") ~ "monday",
      !(day_of_week %in% c("Sat", "Sun", "Mon")) ~ "rest_of_week"
    ) %>% 
      factor(levels = c("rest_of_week", "monday", "weekend")))
}

Custom color palettes, color scales, and vectors of colors:


pal <- c("#006212",
         "#ae3cab",
         "#00db90",
         "#960c00",
         "#55aaff",
         "#ff7e78",
         "#00388d")

age.pal <- viridis::viridis(3,begin = 0.1, end = 0.7)

3 Comparison with deaths time series

3.1 Outline

We want to explore the correlation between NHS Pathways reports and deaths, and assess the potential for reports to be used as an early warning system for disease resurgence.

Death data are publically available. We truncate the time series to avoid bias from reporting delay - we assume a conservative delay of three weeks.

3.2 Lagged correlation

We calculate Pearson’s correlation coefficient between deaths and NHS Pathways notifications using different lags. Confidence intervals are obtained using bootstrap. Note that results were also confirmed using Spearman’s rank correlation.

First we join the NHS Pathways and death data, and aggregate over all England:

## truncate death data for reporting delay
trunc_date <- max(dth$date_report) - delay_max

dth_trunc <- dth %>%
  rename(date = date_report) %>%
  filter(date <= trunc_date) 

## join with notification data
all_data <- x %>% 
  filter(!is.na(nhs_region)) %>%
  group_by(date, nhs_region) %>%
  summarise(count = sum(count, na.rm = T)) %>%
  ungroup %>%
  inner_join(dth_trunc,
             by = c("date","nhs_region"))

all_tot <- all_data %>%
  group_by(date) %>%
  summarise(count = sum(count, na.rm = TRUE),
            deaths = sum(deaths, na.rm = TRUE)) 

We calculate correlation with lagged NHS Pathways reports from 0 to 30 days behind deaths:


## Calculate all correlations + bootstrap CIs
lag_cor <- data.frame()
for (i in 0:30) {
  
  ## lag reports
  summary <- all_tot %>% 
    mutate(note_lag = lag(count, i)) %>%
    ## calculate rank correlation and bootstrap CI
    getboot(.) %>%
    mutate(lag = i)

  lag_cor <- bind_rows(lag_cor, summary)
}

cor_vs_lag <- ggplot(lag_cor, aes(lag, r)) +
  theme_bw() +
  geom_ribbon(aes(ymin = r_low, ymax = r_hi), alpha = 0.2) +
  geom_hline(yintercept = 0, lty = "longdash") +
  geom_point() +
  geom_line() +
  labs(x = "Lag between NHS pathways and death data (days)",
       y = "Pearson's correlation") +
  large_txt
cor_vs_lag


l_opt <- which.max(lag_cor$r)

This analysis suggests that the best lag is 15 days. We then compare and plot the number of deaths reported against the number of NHS Pathways reports lagged by 15 days.


all_tot <- all_tot %>%
  rename(date_death = date) %>%
  mutate(note_lag = lag(count, lag_cor$lag[l_opt]),
         note_lag_c = (note_lag - mean(note_lag, na.rm = T)),
         date_note = lag(date_death,16))

lag_mod <- glm(deaths ~ note_lag, data = all_tot, family = "quasipoisson")

summary(lag_mod)
## 
## Call:
## glm(formula = deaths ~ note_lag, family = "quasipoisson", data = all_tot)
## 
## Deviance Residuals: 
##     Min       1Q   Median       3Q      Max  
## -19.224  -16.063   -4.674    6.336   32.706  
## 
## Coefficients:
##              Estimate Std. Error t value Pr(>|t|)    
## (Intercept) 5.232e+00  6.325e-02  82.719   <2e-16 ***
## note_lag    1.129e-05  1.219e-06   9.262   <2e-16 ***
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for quasipoisson family taken to be 214.6281)
## 
##     Null deviance: 81735  on 329  degrees of freedom
## Residual deviance: 68143  on 328  degrees of freedom
##   (15 observations deleted due to missingness)
## AIC: NA
## 
## Number of Fisher Scoring iterations: 5

exp(coefficients(lag_mod))
## (Intercept)    note_lag 
##  187.223761    1.000011
exp(confint(lag_mod))
##                  2.5 %     97.5 %
## (Intercept) 165.036184 211.495767
## note_lag      1.000009   1.000014

Rsq(lag_mod)
## [1] 0.1662944

mod_fit <- as.data.frame(predict(lag_mod, type = "link", se.fit = TRUE)[1:2])

all_tot_pred <- 
  all_tot %>%
  filter(!is.na(note_lag)) %>%
  mutate(pred = mod_fit$fit,
         pred.se = mod_fit$se.fit,
         low = exp(pred - 1.96*pred.se),
         hi = exp(pred + 1.96*pred.se))


glm_fit <- all_tot_pred %>% 
    filter(!is.na(note_lag)) %>%
  ggplot(aes(x = note_lag, y = deaths)) +
  geom_point() + 
  geom_line(aes(y = exp(pred))) + 
  geom_ribbon(aes(ymin = low, ymax = hi), alpha = 0.3, col = "grey") +
  theme_bw() +
  labs(y = "Daily number of\ndeaths reported",
       x = "Daily number of NHS Pathways reports") +
  large_txt

glm_fit

4 Supplementary figures

4.1 Serial interval distribution

This is a comparison of gamma versus lognormal distribution for the serial interval used to convert r to R in our analysis. Both distributions are parameterised with mean 4.7 and standard deviation 2.9.

SI_param <- epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
                                        shape = SI_param$shape,
                                        scale = SI_param$scale, w = 0.5)

SI_distribution2 <- distcrete::distcrete("lnorm", interval = 1,
                                        meanlog = log(4.7),
                                        sdlog = log(2.9), w = 0.5)

SI_dist1 <- data.frame(x = SI_distribution$r(1e5)) 
SI_dist1 <- count(SI_dist1, x) %>%
    ggplot() +
    geom_col(aes(x = x, y = n)) +
    labs(x = "Serial interval (days)", y = "Frequency") +
    scale_x_continuous(breaks = seq(0, 30, 5)) +
    theme_bw()

SI_dist2 <- data.frame(x = SI_distribution2$r(1e5)) 
SI_dist2 <- count(SI_dist2, x) %>%
    ggplot() +
    geom_col(aes(x = x, y = n)) +
    labs(x = "Serial interval (days)", y = "Frequency") +
    scale_x_continuous(breaks = seq(0, 200, 20), limits = c(0, 200)) +
    theme_bw()


ggpubr::ggarrange(SI_dist1,
                  SI_dist2,
                  nrow = 1,
                  labels = "AUTO") 

4.2 Sensitivity analysis - 7 or 21 days moving window

We reproduce the window analysis with either a 7 or 21 days window for sensitivity purposes.

First with the 7 days window:

## set moving time window (1/2/3 weeks)
w <- 7

# create empty df
r_all_sliding_7days <- NULL

## make data for model
x_model_all_moving <- x %>%
  filter(!is.na(nhs_region)) %>% 
  group_by(date, nhs_region) %>%
  summarise(n = sum(count)) 

unique_dates <- unique(x_model_all_moving$date)

for (i in 1:(length(unique_dates) - w)) {
  
  date_i <- unique_dates[i]
  
  date_i_max <- date_i + w
  
  model_data <- x_model_all_moving %>%
    filter(date >= date_i & date < date_i_max) %>%
    mutate(day = as.integer(date - date_i)) %>% 
    day_of_week()
  
  
  mod <- glm(n ~ day * nhs_region + day_of_week,
             data = model_data,
             family = 'quasipoisson')
  
  # get growth rate
  r <- get_r(mod)
  r$w_min <- date_i
  r$w_max <- date_i_max
  
  # combine all estimates
  r_all_sliding_7days <- bind_rows(r_all_sliding_7days, r)
  
}

#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
                                        shape = SI_param$shape,
                                        scale = SI_param$scale,
                                        w = 0.5)

#convert growth rates r to R0
r_all_sliding_7days <- r_all_sliding_7days %>%
  mutate(R = epitrix::r2R0(r, SI_distribution),
         R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
         R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))
# plot
plot_growth <-
  r_all_sliding_7days %>%
  ggplot(aes(x = w_max, y = r)) +
  geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
  geom_line(aes(colour = nhs_region)) +
  geom_point(aes(colour = nhs_region)) +
  geom_hline(yintercept = 0, linetype = "dashed") +
  theme_bw() +
  scale_weeks +
  theme(legend.position = "bottom",
        plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
  guides(colour = guide_legend(title = "",override.aes = list(fill = NA)), fill = FALSE) +
  labs(x = "",
       y = "Estimated daily growth rate (r)") +
  scale_colour_manual(values = pal)
plot_R <- r_all_sliding_7days %>%
  ggplot(aes(x = w_max, y = R)) +
  geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
  geom_line(aes(colour = nhs_region)) +
  geom_point(aes(colour = nhs_region)) +
  geom_hline(yintercept = 1, linetype = "dashed") +
  theme_bw() +
  scale_weeks +
  theme(legend.position = "bottom",
        plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
  guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
  labs(x = "",
       y = "Estimated effective reproduction\nnumber (Re)") +
  scale_colour_manual(values = pal)

R <- r_all_sliding_7days %>%
  mutate(lower_95 = R_lower_95, 
         upper_95 = R_upper_95,
         value = R,
         measure = "R",
         reference = 1)

r_R <- r_all_sliding_7days %>%
  mutate(measure = "r",
         value = r,
         reference = 0) %>%
  bind_rows(R)

r_R_7 <- r_R %>%
  ggplot(aes(x = w_max, y = value)) +
  geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
  geom_line(aes(colour = nhs_region)) +
  geom_point(aes(colour = nhs_region)) +
  geom_hline(aes(yintercept = reference), linetype = "dashed") +
  theme_bw() +
  scale_weeks +
  theme(legend.position = "bottom",
        plot.margin = margin(0.5,1,0,0, "cm"),
        strip.background = element_blank(),
        strip.placement = "outside"
  ) +
  guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
  labs(x = "", y = "") +
  scale_colour_manual(values = pal) +
  facet_grid(rows = vars(measure),
             scales = "free_y",
             switch = "y",
             labeller = as_labeller(c(r = "Daily growth rate (r)",
                                      R = "Effective reproduction\nnumber (Re)")))

Then with the 21 days window:

## set moving time window (1/2/3 weeks)
w <- 21

# create empty df
r_all_sliding_21days <- NULL

## make data for model
x_model_all_moving <- x %>%
  filter(!is.na(nhs_region)) %>% 
  group_by(date, nhs_region) %>%
  summarise(n = sum(count)) 

unique_dates <- unique(x_model_all_moving$date)

for (i in 1:(length(unique_dates) - w)) {
  
  date_i <- unique_dates[i]
  
  date_i_max <- date_i + w
  
  model_data <- x_model_all_moving %>%
    filter(date >= date_i & date < date_i_max) %>%
    mutate(day = as.integer(date - date_i)) %>% 
    day_of_week()
  
  
  mod <- glm(n ~ day * nhs_region + day_of_week,
             data = model_data,
             family = 'quasipoisson')
  
  # get growth rate
  r <- get_r(mod)
  r$w_min <- date_i
  r$w_max <- date_i_max
  
  # combine all estimates
  r_all_sliding_21days <- bind_rows(r_all_sliding_21days, r)
  
}

#serial interval distribution
SI_param = epitrix::gamma_mucv2shapescale(4.7, 2.9/4.7)
SI_distribution <- distcrete::distcrete("gamma", interval = 1,
                                        shape = SI_param$shape,
                                        scale = SI_param$scale,
                                        w = 0.5)

#convert growth rates r to R0
r_all_sliding_21days <- r_all_sliding_21days %>%
  mutate(R = epitrix::r2R0(r, SI_distribution),
         R_lower_95 = epitrix::r2R0(lower_95, SI_distribution),
         R_upper_95 = epitrix::r2R0(upper_95, SI_distribution))
# plot
plot_growth <-
  r_all_sliding_21days %>%
  ggplot(aes(x = w_max, y = r)) +
  geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
  geom_line(aes(colour = nhs_region)) +
  geom_point(aes(colour = nhs_region)) +
  geom_hline(yintercept = 0, linetype = "dashed") +
  theme_bw() +
  scale_weeks +
  theme(legend.position = "bottom",
        plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
  guides(colour = guide_legend(title = "",override.aes = list(fill = NA)), fill = FALSE) +
  labs(x = "",
       y = "Estimated daily growth rate (r)") +
  scale_colour_manual(values = pal)
# plot
plot_R <-
  r_all_sliding_21days %>%
  ggplot(aes(x = w_max, y = R)) +
  geom_ribbon(aes(ymin = R_lower_95, ymax = R_upper_95, fill = nhs_region), alpha = 0.1) +
  geom_line(aes(colour = nhs_region)) +
  geom_point(aes(colour = nhs_region)) +
  geom_hline(yintercept = 1, linetype = "dashed") +
  theme_bw() +
  scale_weeks +
  theme(legend.position = "bottom",
        plot.margin = margin(0.5,1,0.5,0.5, "cm")) +
  guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
  labs(x = "",
       y = "Estimated effective reproduction\nnumber (Re)") +
  scale_colour_manual(values = pal)

R <- r_all_sliding_21days %>%
  mutate(lower_95 = R_lower_95, 
         upper_95 = R_upper_95,
         value = R,
         measure = "R",
         reference = 1)

r_R <- r_all_sliding_21days %>%
  mutate(measure = "r",
         value = r,
         reference = 0) %>%
  bind_rows(R)

r_R_21 <- r_R %>%
  ggplot(aes(x = w_max, y = value)) +
  geom_ribbon(aes(ymin = lower_95, ymax = upper_95, fill = nhs_region), alpha = 0.1) +
  geom_line(aes(colour = nhs_region)) +
  geom_point(aes(colour = nhs_region)) +
  geom_hline(aes(yintercept = reference), linetype = "dashed") +
  theme_bw() +
  scale_weeks +
  theme(legend.position = "bottom",
        plot.margin = margin(0.5,1,0,0, "cm"),
        strip.background = element_blank(),
        strip.placement = "outside"
  ) +
  guides(color = guide_legend(title = "", override.aes = list(fill = NA)), fill = FALSE) +
  labs(x = "", y = "") +
  scale_colour_manual(values = pal) +
  facet_grid(rows = vars(measure),
             scales = "free_y",
             switch = "y",
             labeller = as_labeller(c(r = "Daily growth rate (r)",
                                      R = "Effective reproduction\nnumber (Re)")))

And we combine both outputs into a single plot:


ggpubr::ggarrange(r_R_7,
                  r_R_21,
                  nrow = 2,
                  labels = "AUTO",
                  common.legend = TRUE,
                  legend = "bottom") 

4.3 Correlation between NHS Pathways reports and deaths by NHS region


lag_cor_reg <- data.frame()

for (i in 0:30) {

  summary <-
    all_data %>%
    group_by(nhs_region) %>%
    mutate(note_lag = lag(count, i)) %>%
    ## calculate rank correlation and bootstrap CI for each region
    group_modify(~getboot(.x)) %>%
    mutate(lag = i)
  
  lag_cor_reg <- bind_rows(lag_cor_reg, summary)
}

cor_vs_lag_reg <- 
lag_cor_reg %>%
ggplot(aes(lag, r, col = nhs_region)) +
  geom_hline(yintercept = 0, lty = "longdash") +
  geom_ribbon(aes(ymin = r_low, ymax = r_hi, col = NULL, fill = nhs_region), alpha = 0.2) +
  geom_point() +
  geom_line() +
  facet_wrap(~nhs_region) +
  scale_color_manual(values = pal) +
  scale_fill_manual(values = pal, guide = F) +  
  theme_bw() +
  labs(x = "Lag between NHS pathways and death data (days)", y = "Pearson's correlation", col = "NHS region") +
  theme(legend.position = "bottom") +
  guides(color = guide_legend(override.aes = list(fill = NA)))

cor_vs_lag_reg

5 Export data

We save the tables created during our analysis:


if (!dir.exists("excel_tables")) {
  dir.create("excel_tables")
}


## list all tables, and loop over export
tables_to_export <- c("r_all_sliding", "lag_cor")

for (e in tables_to_export) {
  rio::export(get(e),
              file.path("excel_tables",
                        paste0(e, ".xlsx")))
}

## also export result from regression on lagged data 
rio::export(lag_mod, file.path("excel_tables", "lag_mod.rds"))

6 System information

6.1 Outline

The following information documents the system on which the document was compiled.

6.2 System

This provides information on the operating system.

Sys.info()
##                                                                                             sysname 
##                                                                                            "Darwin" 
##                                                                                             release 
##                                                                                            "19.6.0" 
##                                                                                             version 
## "Darwin Kernel Version 19.6.0: Tue Jan 12 22:13:05 PST 2021; root:xnu-6153.141.16~1/RELEASE_X86_64" 
##                                                                                            nodename 
##                                                                           "Mac-1616234898957.local" 
##                                                                                             machine 
##                                                                                            "x86_64" 
##                                                                                               login 
##                                                                                              "root" 
##                                                                                                user 
##                                                                                            "runner" 
##                                                                                      effective_user 
##                                                                                            "runner"

6.3 R environment

This provides information on the version of R used:

R.version
##                _                           
## platform       x86_64-apple-darwin17.0     
## arch           x86_64                      
## os             darwin17.0                  
## system         x86_64, darwin17.0          
## status                                     
## major          4                           
## minor          0.4                         
## year           2021                        
## month          02                          
## day            15                          
## svn rev        80002                       
## language       R                           
## version.string R version 4.0.4 (2021-02-15)
## nickname       Lost Library Book

6.4 R packages

This provides information on the packages used:

sessionInfo()
## R version 4.0.4 (2021-02-15)
## Platform: x86_64-apple-darwin17.0 (64-bit)
## Running under: macOS Catalina 10.15.7
## 
## Matrix products: default
## BLAS:   /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRblas.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRlapack.dylib
## 
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] ggnewscale_0.4.5     ggpubr_0.4.0         lubridate_1.7.10    
##  [4] chngpt_2020.10-12    cyphr_1.1.0          DT_0.17             
##  [7] kableExtra_1.3.4     janitor_2.1.0        remotes_2.2.0       
## [10] projections_0.5.2    earlyR_0.0.5         epitrix_0.2.2       
## [13] distcrete_1.0.3      incidence_1.7.3      rio_0.5.26          
## [16] reshape2_1.4.4       rvest_1.0.0          xml2_1.3.2          
## [19] linelist_0.0.40.9000 forcats_0.5.1        stringr_1.4.0       
## [22] dplyr_1.0.5          purrr_0.3.4          readr_1.4.0         
## [25] tidyr_1.1.3          tibble_3.1.0         ggplot2_3.3.3       
## [28] tidyverse_1.3.0      here_1.0.1           reportfactory_0.0.5 
## 
## loaded via a namespace (and not attached):
##  [1] minqa_1.2.4       colorspace_2.0-0  selectr_0.4-2     ggsignif_0.6.1   
##  [5] ellipsis_0.3.1    rprojroot_2.0.2   snakecase_0.11.0  fs_1.5.0         
##  [9] rstudioapi_0.13   farver_2.1.0      fansi_0.4.2       splines_4.0.4    
## [13] knitr_1.31        jsonlite_1.7.2    nloptr_1.2.2.2    broom_0.7.5      
## [17] dbplyr_2.1.0      compiler_4.0.4    httr_1.4.2        backports_1.2.1  
## [21] assertthat_0.2.1  Matrix_1.3-2      cli_2.3.1         htmltools_0.5.1.1
## [25] tools_4.0.4       gtable_0.3.0      glue_1.4.2        Rcpp_1.0.6       
## [29] carData_3.0-4     cellranger_1.1.0  vctrs_0.3.6       svglite_2.0.0    
## [33] nlme_3.1-152      matchmaker_0.1.1  crosstalk_1.1.1   xfun_0.22        
## [37] ps_1.6.0          openxlsx_4.2.3    lme4_1.1-26       lifecycle_1.0.0  
## [41] statmod_1.4.35    rstatix_0.7.0     MASS_7.3-53       scales_1.1.1     
## [45] hms_1.0.0         parallel_4.0.4    sodium_1.1        yaml_2.2.1       
## [49] curl_4.3          gridExtra_2.3     stringi_1.5.3     highr_0.8        
## [53] kyotil_2020.10-12 boot_1.3-26       zip_2.1.1         rlang_0.4.10     
## [57] pkgconfig_2.0.3   systemfonts_1.0.1 evaluate_0.14     lattice_0.20-41  
## [61] labeling_0.4.2    htmlwidgets_1.5.3 cowplot_1.1.1     tidyselect_1.1.0 
## [65] plyr_1.8.6        magrittr_2.0.1    R6_2.5.0          generics_0.1.0   
## [69] DBI_1.1.1         mgcv_1.8-33       pillar_1.5.1      haven_2.3.1      
## [73] foreign_0.8-81    withr_2.4.1       survival_3.2-7    abind_1.4-5      
## [77] modelr_0.1.8      crayon_1.4.1      car_3.0-10        utf8_1.2.1       
## [81] rmarkdown_2.7     viridis_0.5.1     grid_4.0.4        readxl_1.3.1     
## [85] data.table_1.14.0 reprex_1.0.0      digest_0.6.27     webshot_0.5.2    
## [89] munsell_0.5.0     viridisLite_0.3.0